HiLDA - Conducting statistical inference on comparing the mutational exposures of mutational signatures by using hierarchical latent Dirichlet allocation
A package built under the Bayesian framework of applying hierarchical latent Dirichlet allocation. It statistically tests whether the mutational exposures of mutational signatures (Shiraishi-model signatures) are different between two groups. The package also provides inference and visualization.
Last updated 5 months ago
softwaresomaticmutationsequencingstatisticalmethodbayesianmutational-signaturesrjagssomatic-mutations
3 stars 5.56 score 105 dependencies 1 dependentsselectKSigs - Selecting the number of mutational signatures using a perplexity-based measure and cross-validation
A package to suggest the number of mutational signatures in a collection of somatic mutations using calculating the cross-validated perplexity score.
Last updated 5 months ago
softwaresomaticmutationsequencingstatisticalmethodclusteringmutational-signaturesrjagssomatic-mutations
3 stars 4.08 score 107 dependencies